Humira Adalimumab Drug Injection is a brand name of prescription medicine used to treat swelling and inflammation conditions. It improves joint function.
● Rheumatoid arthritis
● Juvenile idiopathic arthritis in children
● Psoriatic arthritis
● Ankylosing spondylitis
● Plaque psoriasis
● Crohn’s disease
● Ulcerative colitis
● Hidradenitis suppurativa
● Certain types of uveitis
Humira is a branded prescription medication with adalimumab as its active
ingredient, classified as a biologic drug.
What is the mechanism of action of the drug Humira Adalimumab?
Adalimumab is a targeted therapy known as a tumor necrosis factor (TNF) inhibitor, designed to mitigate inflammation by interfering with the action of TNF, a protein that drives the inflammatory process. It functions through several mechanisms:
● Prevents TNF from Binding to Healthy Cells: Adalimumab effectively blocks
TNF from attaching to and damaging healthy cells, thereby reducing
inflammation.
● Induces Apoptosis in TNF-Expressing Cells: This medication promotes
apoptosis, or programmed cell death, in mononuclear cells that produce TNF,
further reducing inflammation.
● Inhibits the Inflammatory Cascade: Adalimumab disrupts the chain reaction of
inflammatory processes, which is crucial in managing conditions like psoriatic
skin lesions.
What is the Class or Category of Drugs?
Adalimumab falls under the category of tumor necrosis factor (TNF) inhibitors, a group of drugs that function by targeting and blocking the action of TNF, a protein produced by the body that plays a role in inflammation.
How should you use a dosage of this medicine?
Humira is available in three different formats:
- a single-dose pen,
- a prefilled single-dose syringe, and
- a single-dose vial of liquid.
The medication is administered through a subcutaneous injection. That means it is administered under the skin. While a healthcare professional can perform these
injections for you, with your doctor’s consent and proper training, you may be able to self-administer using the pen or syringe. Note that the vial form of Humira is strictly for use by healthcare professionals and is not intended for patient self-administration.
- It is generally given as 80 mg or 8 ml.
- It is also available in 40 mg or 4ml.
What are the Common side effects of Humira?
Any one of the side effects or more than one side effect can be observed.
● Injection site reactions (pain, itching, swelling near the injection spot)
● Headache
● Common Cold
● Unusual weakness or fatigue,
● Nausea
● Diarrhea
● Cough
● Rash
● Hives
● Dizziness
Where are the Serious side effects and Contradictions of Humira?
Any one of the side effects or more than one side effect can be observed.
1. Shortness of breath-like feeling (e.g. uneasiness, fear)
2. Cancer (e.g., lymphoma, skin cancer)
3. Neurological problems (e.g., multiple sclerosis, seizures)
4. Cardiovascular events (e.g., heart attack, stroke)
5. Allergic reactions
What are the Serious Contradiction of Humira?
Humira impacts your immune system, as it contains adalimumab, which can reduce your body’s ability to combat infections. Consequently, you might be more susceptible to infections. In some cases, these infections, which can be caused by viruses, fungi, or bacteria have led to severe complications or even death.
One serious infection to be aware of is tuberculosis (TB). Your doctor must test you for TB both before initiating and during your Humira treatment.
If you experience any signs of infection—such as fever, chills, body aches, fatigue,
cough, skin sores, diarrhea, or a burning sensation while urinating—inform your doctor immediately.
Which is the route of administration for Humira (adalimumab)?
1. Humira is administered via injection (pen or syringe).
2. Typically injected every other week.
3. Dosage varies depending on condition and patient response.
Important considerations:
● Consult your doctor before starting Humira.
● Ensure you’re up-to-date on vaccinations before starting treatment.
● Monitor for signs of infection or other side effects.
● Regular blood tests and check-ups are necessary.
What are Alternative Brand names and Alternative Brands for Humora Injection?
Following are the different alternative brands available for the Humora Injection with the prices or costs of each.
| Company | Price Range |
|---|---|
| Adfrar Torrent Pharmaceuticals Ltd | ₹10,500 to ₹25,000 |
| Adaly Glenmark Pharmaceuticals Ltd | ₹24,900 |
| Envira Emcure Pharmaceuticals Ltd | ₹23,437 |
| Mabura Hetero Drugs Ltd | ₹25,000 |
| Plamumab Cipla Ltd | ₹26,353 |
| Adalimac Macleods Pharmaceuticals Pvt Ltd | ₹22,321 |
| Mabvinra Alkem Laboratories Ltd | ₹9,999 to ₹23,999 |
| Adalirel Reliance Life Sciences | ₹11,000 to ₹22,000 |
| Amab Dr Reddy’s Laboratories Ltd | ₹25,000 |
| Admira Tricept Life Sciences Private Limited | ₹26,000 |
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